Changes in pathophysiology of tumor growth and functional activity of the hypothalamic-pituitary-thyroid axis in rats of both sexes with the development of Guerin's carcinoma on the background of hypothyroidism

Purpose of the study . Was to analyze changes in pathophysiological parameters transplantable tumor growth and functional activity hypothalamic-pituitary-thyroid axis (HPT) rats both sexes with Guerin's carcinoma presence induced hypothyroidism. Materials methods The dynamics average life span were assessed white alley Guerins transplanted subcutaneously on background thyreostatic RIA (radioimmune assay) ELISA (enzyme-linked immunosorbent used determine levels thyroid hormones blood samples, thyrotropin-releasing hormone (TRH) hypothalamus, as well TSH pituitary gland. experiment included 2 control groups: animals hypothyroidism (control group 1, number rodents = 15) without 2, 15). Results Hypothyroidism female inhibited improved median survival by 1.8 times (p < 0.05). No such effect was observed males main group. Levels regulatory peptides hypothalamus gland declined females group, while increased, despite a decrease TRH 3.5 times. decreased sexes; however, total free circulating thyroxine (T4 FT4) 1.6 2.8 found tumor, respectively; samples remained saturated T4 FT4 Conclusions gender differences pathophysiology development hypothyroidism, HPT experimental revealed this can probably be associated sex hormones, which requires further hypothalamic-pituitary-gonadal (HPG) steroid peripheral organs samples.